Model Internals

Each PhenDB model is trained on sets of bacterial ENOGs (orthologous groups from EggNOG 4.5), which have or have not been identified in the training genomes. Each ENOG is given a weight, with the magnitude of the weight being the importance of that ENOG for the final prediction. The sign of the weight indicates whether the presence (positive weight) or absence (negative weight) of this ENOG is indicative of the trait.

This table lists the 250 highest-ranking ENOGs of this model.

rank in model enog name enog description weight in model
1 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) -0.012597
2 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) -0.012497
3 ENOG4105CK6 Two component transcriptional regulator (Winged helix family -0.012174
4 ENOG4105C6T cysteine synthase -0.012083
5 ENOG4105C01 Dihydroxy-acid dehydratase -0.011917
6 ENOG4105CQC Prephenate dehydratase -0.011544
7 ENOG4105EVN Prephenate dehydrogenase -0.011275
8 ENOG4108ZP8 Acetolactate synthase small subunit -0.010869
9 ENOG4105CBC glutamate synthase -0.010740
10 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) -0.010537
11 ENOG4105DK0 Indole-3-glycerol phosphate synthase -0.010537
12 ENOG4105D06 uba thif-type nad fad binding protein -0.010499
13 ENOG4105CHM Aminotransferase -0.010335
14 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase -0.010196
15 ENOG4105DFA alanine racemase domain protein -0.010105
16 ENOG4105C7K acetolactate synthase -0.009921
17 ENOG4105WPN DNA integration recombination invertion protein -0.009795
18 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) -0.009763
19 ENOG4105C12 Phosphoribosylglycinamide synthetase -0.009667
20 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) -0.009614
21 ENOG4105CDH Citrulline--aspartate ligase -0.009387
22 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) -0.009383
23 ENOG4106NDE Ammonium Transporter Family -0.009224
24 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) -0.009207
25 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) -0.009118
26 ENOG4105CH7 arginosuccinase -0.009029
27 ENOG4105C7N Xanthine uracil vitamin C permease -0.008938
28 ENOG4105D6E homoserine dehydrogenase -0.008937
29 ENOG4105II7 pyrroline-5-carboxylate reductase -0.008861
30 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase -0.008844
31 ENOG4105CM2 brancheD-chain amino acid aminotransferase -0.008837
32 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase -0.008832
33 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) -0.008686
34 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase -0.008663
35 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase -0.008618
36 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) -0.008599
37 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase -0.008592
38 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) 0.008416
39 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) -0.008246
40 ENOG4107QKA exodeoxyribonuclease V beta 0.008224
41 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) -0.008155
42 ENOG4105D49 3-dehydroquinate synthase -0.008118
43 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) -0.008053
44 ENOG4105ECC imidazole-glycerol-phosphate dehydratase -0.008000
45 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) -0.007966
46 ENOG4105KTH gatB Yqey -0.007961
47 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) -0.007948
48 ENOG4105CQB FAD linked oxidase domain protein -0.007945
49 ENOG4105E2X shikimate dehydrogenase -0.007889
50 ENOG4105EB3 Histidine kinase -0.007848
51 ENOG4108JQC penicillin-binding protein 1A -0.007836
52 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) -0.007794
53 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) -0.007768
54 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase -0.007727
55 ENOG4108JQ6 ABC transporter -0.007717
56 ENOG4108JQ1 Dehydrogenase -0.007686
57 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) -0.007675
58 ENOG4105CHU acetyl-coa acetyltransferase -0.007638
59 ENOG4105C9A Phoh family -0.007569
60 ENOG4105EAC phosphoserine phosphatase -0.007560
61 ENOG4108V3E phosphoribosylglycinamide formyltransferase -0.007531
62 ENOG4105DWV Homoserine O-trans-acetylase -0.007472
63 ENOG4105C5I Dehydrogenase -0.007437
64 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase -0.007433
65 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) -0.007391
66 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) -0.007300
67 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) -0.007284
68 ENOG4105C59 p-type ATPase -0.007225
69 ENOG4108YZA Nitrogen regulatory protein pii -0.007179
70 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase -0.007143
71 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) -0.007135
72 ENOG4108SEK ompa motb domain protein -0.007114
73 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase -0.007112
74 ENOG4105CXT aspartate transcarbamylase -0.007107
75 ENOG4105WMR Protein CrcB homolog -0.007100
76 ENOG4105CE1 Ferrous iron transport protein b -0.007066
77 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase -0.007059
78 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) -0.007019
79 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) -0.006914
80 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) -0.006892
81 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase -0.006843
82 ENOG4105CJT Mannose-1-phosphate guanylyltransferase -0.006842
83 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) -0.006811
84 ENOG4105CRQ synthase (Component I) -0.006809
85 ENOG4107QJR hflk protein 0.006806
86 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) -0.006742
87 ENOG4105D7W serine acetyltransferase -0.006719
88 ENOG4105C37 (CBS) domain -0.006717
89 ENOG4107VS1 KR domain -0.006716
90 ENOG4108Z0R Transferase -0.006702
91 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) -0.006685
92 ENOG4105DC1 bifunctional purine biosynthesis protein purh -0.006680
93 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) -0.006653
94 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase -0.006651
95 ENOG41090R7 Ferric uptake -0.006636
96 ENOG4105DPZ Two component transcriptional regulator (Winged helix family -0.006634
97 ENOG4107QZU type I restriction-modification system -0.006633
98 ENOG4105DJQ tetratricopeptide tpr_2 repeat protein -0.006613
99 ENOG4105CJ1 ABC, transporter -0.006604
100 ENOG4105DX0 Hemolysin A -0.006533
101 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) -0.006492
102 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) -0.006462
103 ENOG4105E7T carrier protein 0.006439
104 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) -0.006415
105 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) -0.006407
106 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) -0.006407
107 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) -0.006386
108 ENOG4105CFP Peptidase U32 -0.006365
109 ENOG4107QUS 2-isopropylmalate synthase homocitrate synthase family protein -0.006359
110 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) -0.006352
111 ENOG4107R37 Glutamate dehydrogenase -0.006333
112 ENOG4105CXB phosphoribosylaminoimidazole synthetase -0.006308
113 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) -0.006308
114 ENOG4107RR9 sulfate transporter -0.006289
115 ENOG4108VPT UPF0234 protein -0.006279
116 ENOG4108UHU Aldolase -0.006269
117 ENOG4105DWF phosphomethylpyrimidine kinase -0.006254
118 ENOG4105C83 adenylosuccinate lyase -0.006246
119 ENOG4105DBV ornithine carbamoyltransferase -0.006211
120 ENOG4105EJQ L-serine dehydratase -0.006159
121 ENOG4105CKU formyltetrahydrofolate synthetase -0.006158
122 ENOG4105BZ8 glutamate synthase -0.006157
123 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase -0.006155
124 ENOG4105C30 Nad-dependent epimerase dehydratase -0.006142
125 ENOG4105CAS nag kinase -0.006122
126 ENOG4105CH2 amidohydrolase -0.006121
127 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) -0.006087
128 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) -0.006027
129 ENOG4105D8V Glucose sorbosone dehydrogenase -0.006009
130 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) -0.006009
131 ENOG4105CN1 protease -0.006000
132 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) -0.005990
133 ENOG4105D4P Coproporphyrinogen iii oxidase -0.005969
134 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor -0.005960
135 ENOG4108I0Q anthranilate phosphoribosyltransferase -0.005958
136 ENOG4107YD3 Thioesterase -0.005947
137 ENOG4105ERH Fumarylacetoacetate hydrolase -0.005930
138 ENOG4105D1H recombination factor protein RarA -0.005927
139 ENOG4108V06 Glutathione peroxidase -0.005898
140 ENOG4105DWY Agmatine deiminase -0.005889
141 ENOG4105D2N Aldolase -0.005871
142 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) -0.005868
143 ENOG4105CZX twitching motility protein -0.005846
144 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) -0.005820
145 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) -0.005808
146 ENOG4105C98 muts2 protein -0.005785
147 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC -0.005782
148 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase -0.005775
149 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) -0.005754
150 ENOG4105C0Z ABC transporter -0.005753
151 ENOG4105CA0 peroxidase -0.005746
152 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) -0.005736
153 ENOG4105CDA abc transporter atp-binding protein -0.005726
154 ENOG4108IYU L-aspartate oxidase -0.005700
155 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) -0.005698
156 ENOG4105BZJ Electron transfer flavoprotein -0.005682
157 ENOG4105C10 Electron transfer flavoprotein -0.005682
158 ENOG4105DGU Histone deacetylase -0.005675
159 ENOG410741R Methionine biosynthesis protein MetW -0.005651
160 ENOG4105C8J )-transporter -0.005646
161 ENOG4105C28 cystathionine -0.005643
162 ENOG4105KME endoribonuclease L-psp -0.005635
163 ENOG4108UTW Plays a role in the regulation of phosphate uptake -0.005619
164 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain -0.005603
165 ENOG4105VDU S-adenosyl-l-methionine hydroxide adenosyltransferase -0.005583
166 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase -0.005551
167 ENOG4105C0K Gdp-mannose 4,6-dehydratase -0.005548
168 ENOG4107TH8 cina domain protein -0.005531
169 ENOG4105C9X ppx gppa phosphatase -0.005521
170 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F -0.005520
171 ENOG4105CFB Gamma-glutamyltranspeptidase (EC -0.005516
172 ENOG4107SK0 cytochrome c biogenesis protein -0.005514
173 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component -0.005505
174 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) 0.005488
175 ENOG4105E0F Histidine kinase -0.005481
176 ENOG4105C45 hydrogenase expression formation protein (HypE) -0.005475
177 ENOG4108M36 Histidine kinase -0.005467
178 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I -0.005467
179 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) -0.005458
180 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) -0.005454
181 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) -0.005440
182 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) -0.005429
183 ENOG4108IQE Amp-dependent synthetase and ligase -0.005425
184 ENOG4105DHP deoxycytidine triphosphate deaminase -0.005417
185 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) -0.005403
186 ENOG4105D64 Mechanosensitive ion channel -0.005344
187 ENOG4105C5E polysaccharide biosynthesis protein -0.005337
188 ENOG4105FF2 Type I DHQase -0.005336
189 ENOG4105FEU K -dependent Na -Ca exchanger -0.005333
190 ENOG41089BK Glutamine amido-transferase -0.005313
191 ENOG4105NXV High-affinity zinc uptake system protein 0.005306
192 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) 0.005306
193 ENOG4105CVM Molybdenum cofactor synthesis domain protein -0.005292
194 ENOG4105D22 carbon starvation protein -0.005292
195 ENOG4107R61 decarboxylase -0.005256
196 ENOG4108UNV SUF system FeS assembly protein, NifU family -0.005246
197 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) -0.005245
198 ENOG4105CQS hydrogenase expression formation protein HypD -0.005218
199 ENOG4105E2S oxidase) subunit II 0.005216
200 ENOG4108UVB (LipO)protein -0.005210
201 ENOG4105N6D Fimbrial assembly family protein -0.005207
202 ENOG41068TE Rare lipoprotein B -0.005186
203 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) -0.005185
204 ENOG4105DMF Dehydrogenase -0.005178
205 ENOG4105K70 DNA-binding protein -0.005178
206 ENOG4105D8D Type III -0.005151
207 ENOG4105KDC 50s ribosomal protein l28 0.005137
208 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) -0.005133
209 ENOG4105KNE Phosphatidate cytidylyltransferase -0.005127
210 ENOG4105CTQ phosphohexokinase -0.005098
211 ENOG4105CFH Aspartokinase -0.005097
212 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) -0.005068
213 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation -0.005043
214 ENOG4107R3R Cytochrome o ubiquinol oxidase subunit III 0.005042
215 ENOG4105CSR polyphosphate kinase 2 -0.005038
216 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) -0.005034
217 ENOG4107QWH The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) -0.005013
218 ENOG4105M8F Biopolymer transport protein exbD tolR -0.005012
219 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) -0.005003
220 ENOG4105CIH Imidazole acetol-phosphate transaminase -0.004991
221 ENOG4108IQK o-acetylhomoserine -0.004965
222 ENOG4105C5F glutamine synthetase -0.004955
223 ENOG4108R7S Histidine triad (Hit) protein -0.004932
224 ENOG4105Q8M Hnh endonuclease -0.004928
225 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase -0.004912
226 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) 0.004903
227 ENOG4105CAK Cell division ATP-binding protein ftsE -0.004894
228 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein -0.002437
228 ENOG4105DQU oxidoreductase, subunit beta -0.002437
229 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) -0.004868
230 ENOG4105D4A Cell wall formation (By similarity) -0.004863
231 ENOG4107EXU Short-chain dehydrogenase reductase Sdr -0.004860
232 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis -0.004855
233 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) -0.004853
234 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase -0.004849
235 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme -0.004832
236 ENOG4108ZCE endoribonuclease L-psp -0.004802
237 ENOG4105CB5 ATP-dependent DNA helicase recG -0.004796
238 ENOG4105CH6 catalase -0.004789
239 ENOG4105DVC DnaJ domain protein -0.004780
240 ENOG4105EAH synthase -0.004778
241 ENOG4105E2Z phosphate ABC transporter (Permease -0.004763
242 ENOG4105C7I Dehydrogenase 0.004754
243 ENOG4105CYM Glutathione S-transferase -0.004753
244 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) -0.004743
245 ENOG4105FE1 phytoene synthase -0.004731
246 ENOG4105HMI Membrane -0.004728
247 ENOG4107QV2 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) 0.004728
248 ENOG4105W0E 50S ribosomal protein L33 0.004721
249 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain -0.004718