Model Internals

Each PhenDB model is trained on sets of bacterial ENOGs (orthologous groups from EggNOG 4.5), which have or have not been identified in the training genomes. Each ENOG is given a weight, with the magnitude of the weight being the importance of that ENOG for the final prediction. The sign of the weight indicates whether the presence (positive weight) or absence (negative weight) of this ENOG is indicative of the trait.

This table lists the 250 highest-ranking ENOGs of this model.

rank in model enog name enog description weight in model
1 ENOG4105E80 TraG TraD family protein 0.014907
2 ENOG4105EJX conjugal transfer ATPase 0.013644
3 ENOG4105C7I Dehydrogenase 0.011679
4 ENOG4105K59 histidine triad (HIT) protein 0.011418
5 ENOG4105CSH Transporter 0.011269
6 ENOG4108V42 Type IV secretion system protein VirB8 0.010257
7 ENOG4106TFY DSBA oxidoreductase 0.010227
8 ENOG4108UUM single-stranded DNA-binding protein 0.010190
9 ENOG4105C72 UPF0176 protein 0.009929
10 ENOG4105E76 ribonuclease BN 0.009737
11 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) 0.009717
12 ENOG4105CMA conjugation trbi family protein 0.009678
13 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins 0.009648
14 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) -0.009635
15 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) 0.009543
16 ENOG4105D3R alkyl hydroperoxide reductase 0.009491
17 ENOG4108XQC type IV secretion system protein VirB10 0.009259
18 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase -0.009195
19 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) 0.009103
20 ENOG4108IEH NADH dehydrogenase subunit g 0.009024
21 ENOG4108Z1B Cyclase dehydrase 0.008898
22 ENOG4105DHZ alpha beta 0.008727
23 ENOG4107RUW arginyl-trna synthetase 0.008663
24 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) 0.008646
25 ENOG4107R0V Pyruvate dehydrogenase 0.008584
26 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) -0.008570
27 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) 0.008539
28 ENOG4105EFC phage portal protein HK97 family 0.008538
29 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) 0.008520
30 ENOG4105PDG Type IV secretion system protein VirB8 0.008495
31 ENOG4105CIH Imidazole acetol-phosphate transaminase -0.008466
32 ENOG4105C79 DNA protecting protein DprA 0.008460
33 ENOG4107QW9 peptidase, M24 0.008414
34 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) -0.008287
35 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) 0.008281
36 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) -0.008236
37 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) 0.008216
38 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) 0.008205
39 ENOG4105C75 arginyL-tRNA synthetase -0.008165
40 ENOG4105CFQ glutamine synthetase 0.008163
41 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) -0.008108
42 ENOG4108TEB UPF0114 protein 0.008102
43 ENOG4107S72 Competence protein 0.008057
44 ENOG4105C38 Glycyl-tRNA synthetase beta subunit 0.008040
45 ENOG4105EDR glucose galactose transporter 0.007993
46 ENOG4107QM5 aconitate hydratase 0.007958
47 ENOG4105VXN addiction module toxin, RelE StbE family 0.007938
48 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase -0.007912
49 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) 0.007879
50 ENOG4105K6T rare lipoprotein A 0.007846
51 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) 0.007823
52 ENOG4105ECC imidazole-glycerol-phosphate dehydratase -0.007790
53 ENOG4105C02 permease 0.007784
54 ENOG41076HS cation diffusion facilitator family transporter 0.007783
55 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase -0.007774
56 ENOG4105DWV Homoserine O-trans-acetylase -0.007756
57 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain 0.007727
58 ENOG4107TZQ ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family 0.007710
59 ENOG4108TGY Glutathione S-transferase 0.007704
60 ENOG4107VS1 KR domain 0.007695
61 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) -0.007686
62 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) -0.007653
63 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) -0.003826
63 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) -0.003826
64 ENOG4105DVC DnaJ domain protein 0.007641
65 ENOG4105Y3C ABC, transporter 0.007625
66 ENOG4105EGP transfer protein 0.007603
67 ENOG4107QP7 CoA-transferase subunit A 0.007554
68 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) -0.007541
69 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase -0.007539
70 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) 0.007537
71 ENOG4108IJ8 ABC transporter 0.007511
72 ENOG4108Z4U Ferredoxin 0.007498
73 ENOG4108I28 Type IV secretion system ATPase 0.007445
74 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase 0.007413
75 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) 0.007392
76 ENOG4105WVQ Fe-S assembly protein IscX 0.007390
77 ENOG4107RP6 DegT/DnrJ/EryC1/StrS aminotransferase family 0.007382
78 ENOG4105E0U tyrosine-specific transport protein 0.007348
79 ENOG41068E8 Chorismate mutase 0.007346
80 ENOG4105DQ4 alcohol dehydrogenase 0.007304
81 ENOG4108YXA Membrane 0.007282
82 ENOG4105CA9 Pyruvate kinase -0.007276
83 ENOG4108UHU Aldolase 0.007274
84 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) 0.007252
85 ENOG4105C5I Dehydrogenase -0.007243
86 ENOG4105BZG amino acid carrier protein 0.007238
87 ENOG4105ZCD auxin efflux carrier 0.007236
88 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) 0.007192
89 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) 0.007175
90 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) 0.007154
91 ENOG4106CJB Phospholipase Carboxylesterase 0.007131
92 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain 0.007099
93 ENOG4108K2X pilus assembly 0.007087
94 ENOG4105D60 lipoprotein releasing system transmembrane protein 0.007079
95 ENOG4105EAH synthase 0.007039
96 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) -0.007031
97 ENOG4108PCE TRANSFER protein 0.007004
98 ENOG4105CGK Exodeoxyribonuclease III 0.006959
99 ENOG4105D65 subunit l 0.006958
100 ENOG4105DAN ATP-dependent protease -0.006912
101 ENOG4105EFQ Two component transcriptional regulator (Winged helix family 0.001725
101 ENOG4105REZ Stringent starvation protein B 0.001725
101 ENOG4107RCQ (CBS) domain 0.001725
101 ENOG4107RMM double-strand break repair protein Addb 0.001725
102 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB 0.006887
103 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) 0.006873
104 ENOG4105CS9 pantothenic acid kinase 0.006872
105 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) 0.006860
106 ENOG4105E9Q Acyl-transferase 0.006855
107 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) 0.006854
108 ENOG4105KEG ribosomal-protein-alanine acetyltransferase 0.006848
109 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) 0.006811
110 ENOG4105CG5 Glycosyl transferase (Group 1 -0.006796
111 ENOG4108KCE plasmid partition ParA protein -0.006783
112 ENOG4105D7Q type ii secretion system -0.006747
113 ENOG4105DVF Cytosine-specific methyltransferase 0.006744
114 ENOG4107RZC phospholipase d 0.006737
115 ENOG4105C8S subunit m 0.006735
116 ENOG4108ZP8 Acetolactate synthase small subunit -0.006733
117 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane 0.006729
118 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) 0.006727
119 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) 0.006714
120 ENOG4105VQU rdd domain containing protein 0.006707
121 ENOG4107QNT pyruvate dehydrogenase e1 component suBunit beta 0.006677
122 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) 0.006658
123 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation 0.006620
124 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen 0.006597
125 ENOG4105HD3 Conserved Protein 0.006594
126 ENOG4105C5G amine oxidase -0.006575
127 ENOG4105CG6 trap dicarboxylate transporter dctm subunit -0.006565
128 ENOG4105BZ9 Cytochrome C oxidase, subunit I 0.006561
129 ENOG4105CUG Oligopeptidase b 0.006528
130 ENOG4108S0N Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity) 0.006526
131 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit -0.006501
132 ENOG4105K8R UPF0145 protein -0.006499
133 ENOG41084B3 50S ribosomal protein l34 0.006489
134 ENOG410618E NA 0.000721
134 ENOG41066R0 Membrane 0.000721
134 ENOG4108AMH Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) 0.000721
134 ENOG4108KAG Cytochrome C oxidase, subunit I 0.000721
134 ENOG4108NG5 type IV secretion system protein 0.000721
134 ENOG4108NGE Type IV secretion system protein VirB6 0.000721
134 ENOG4108QTG type IV secretion system protein 0.000721
134 ENOG4108R2G tpr domain protein 0.000721
134 ENOG4108XJA Type IV secretion system protein VirB9 0.000721
135 ENOG4107YJP 5-formyltetrahydrofolate cyclo-ligase 0.006461
136 ENOG4108RCN Conjugative transfer protein TraG 0.006422
137 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) 0.006421
138 ENOG4105EIX cytochrome c1 0.006418
139 ENOG4105CSR polyphosphate kinase 2 -0.006409
140 ENOG410696E Membrane 0.006398
141 ENOG4108X6C Conjugal transfer mating pair stabilization protein TraN 0.006389
142 ENOG4105K7A Phage prohead protease, HK97 family 0.006367
143 ENOG4105DQE DNA ligase 0.006366
144 ENOG4105CKU formyltetrahydrofolate synthetase -0.006363
145 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) 0.006338
146 ENOG41060IM Heme exporter protein 0.006321
147 ENOG4105VM1 flagellar 0.006315
148 ENOG4105D5Q Arginine ornithine antiporter 0.006307
149 ENOG4105C2C drug resistance transporter, Bcr CflA 0.006290
150 ENOG4105KTH gatB Yqey -0.006287
151 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) 0.006272
152 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) -0.006218
153 ENOG4105EJQ L-serine dehydratase 0.006214
154 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) -0.006205
155 ENOG4105E33 succinate dehydrogenase 0.006197
156 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) -0.006185
157 ENOG4107VCP Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) 0.006175
158 ENOG4106WJS phage protein 0.006171
159 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) 0.006162
160 ENOG4105CJW magnesium transporter -0.006155
161 ENOG4105G9V cytochrome C 0.006136
162 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) 0.006101
163 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) 0.006097
164 ENOG4105EUJ GTP cyclohydrolase i 0.006094
165 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) 0.006085
166 ENOG4105W5Q DNA repair protein (RadC 0.006016
167 ENOG4106B21 frataxin-like protein 0.006010
168 ENOG4105E00 20S proteasome, A and B subunits -0.005999
169 ENOG4106GNM Two component transcriptional regulator (Winged helix family 0.005996
170 ENOG410833S tail length tape measure 0.005987
171 ENOG4108WRK Transcriptional regulator 0.005986
172 ENOG4107RF0 pyruvate dehydrogenase 0.005985
173 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) -0.005977
174 ENOG4105ETE Transcriptional regulator (LacI family 0.005976
175 ENOG4105E9P Phage major capsid protein 0.005966
176 ENOG4105C8B TIGR00159 family -0.005950
177 ENOG4105E90 ABC transporter 0.005944
178 ENOG4107TEB Ankyrin repeat 0.005940
179 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic 0.005934
180 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase -0.005924
181 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA 0.005923
182 ENOG4105BZN citrate synthase 0.005913
183 ENOG4105C59 p-type ATPase -0.005904
184 ENOG4105FDK ABC transporter -0.005899
185 ENOG4105DHP deoxycytidine triphosphate deaminase 0.005878
186 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) -0.005877
187 ENOG4105C03 ribonuclease -0.005876
188 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) 0.005862
189 ENOG4105US7 Histidine kinase 0.005860
190 ENOG4106J2A sn-glycerol-3-phosphate ABC transporter, permease 0.005849
191 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) 0.005849
192 ENOG4107PHU transfer protein TraU 0.005848
193 ENOG4105CEY Amp-dependent synthetase and ligase -0.005847
194 ENOG4105KNA -acetyltransferase 0.005847
195 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) 0.005847
196 ENOG41080FQ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) 0.005846
197 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) 0.005838
198 ENOG4105DA4 cytochrome c-type biogenesis protein 0.005831
199 ENOG4106T9E Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) 0.005812
200 ENOG4108JJ6 Type I secretion system ATPase 0.005807
201 ENOG4105D3Q Sugar transferase -0.005803
202 ENOG41090CK monovalent cation H antiporter subunit B 0.005798
203 ENOG4105MJ3 NADH-ubiquinone oxidoreductase chain 4l 0.005798
204 ENOG41062Y5 N utilization substance protein B 0.005795
205 ENOG4105D07 Signal peptide peptidase, SppA 0.005794
206 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) 0.005785
207 ENOG4105CX6 glutaminyL-tRNA synthetase -0.005783
208 ENOG4108Z4C Uncharacterized protein conserved in bacteria (DUF2237) -0.005772
209 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase 0.005757
210 ENOG4107QIS sua5 ycio yrdc ywlc family protein 0.005752
211 ENOG4107QMH DNA methylase 0.005751
212 ENOG4108KTQ Methyltransferase -0.005737
213 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) 0.005732
214 ENOG4108Z4V iron-sulfur cluster assembly 0.005729
215 ENOG4105D6Z AFG1 family ATPase 0.005714
216 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) 0.005713
217 ENOG41061KU NA 0.002852
217 ENOG41086WG Sel1 repeat 0.002852
218 ENOG4105VR9 phosphoribosylformylglycinamidine synthase -0.005703
219 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) -0.005699
220 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit 0.005691
221 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) 0.005685
222 ENOG4108IQI permease 0.005684
223 ENOG4107XQ8 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) -0.005679
224 ENOG4108Z1M DSBA oxidoreductase -0.005676
225 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ 0.005662
226 ENOG4105C0I Conserved Protein -0.005659
227 ENOG41087AY ADP-Ribose pyrophosphatase -0.005656
228 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) 0.005655
229 ENOG410801S Inherit from COG: Glycosyl transferase, family 2 -0.005641
230 ENOG4105VIE preprotein translocase, subunit YajC 0.005636
231 ENOG4107QPT Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) -0.005623
232 ENOG4105CSX c4-dicarboxylate anaerobic carrier 0.005620
233 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) -0.005616
234 ENOG4105JEU Glycosyl transferase, family 2 -0.005613
235 ENOG41078ZG Major Facilitator superfamily 0.005598
236 ENOG4107EDJ NA 0.005598
237 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) -0.005594