Model Internals

Each PhenDB model is trained on sets of bacterial ENOGs (orthologous groups from EggNOG 4.5), which have or have not been identified in the training genomes. Each ENOG is given a weight, with the magnitude of the weight being the importance of that ENOG for the final prediction. The sign of the weight indicates whether the presence (positive weight) or absence (negative weight) of this ENOG is indicative of the trait.

This table lists the 250 highest-ranking ENOGs of this model.

rank in model enog name enog description weight in model
1 ENOG4106RI5 Met-10+ like-protein 0.009430
2 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) -0.009381
3 ENOG4105CDI RIO1 ZK632.3 MJ0444 family protein 0.009304
4 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) 0.009297
5 ENOG41087Q9 Chaperonin Cpn60 TCP-1 0.009281
6 ENOG4107TIA phenylalanyl-tRNA synthetase (beta subunit) 0.009275
7 ENOG4108K3F N(2),N(2)-dimethylguanosine tRNA methyltransferase 0.009273
8 ENOG4108DNT gtp-binding protein 0.009106
9 ENOG4105C0B DNA polymerase III (alpha subunit) -0.009097
10 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) -0.009078
11 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) -0.009054
12 ENOG4105CQ2 DNA polymerase 0.009044
13 ENOG4107QRT dEAD DEAH box helicase 0.009040
14 ENOG4108FF0 adenylate kinase (EC 2.7.4.3) 0.009021
15 ENOG4105K46 50S ribosomal protein l27 -0.009017
16 ENOG4105HDK L-asparaginase 0.008865
17 ENOG4105TV7 Peptide Chain Release Factor 0.008803
18 ENOG4105E0R Deoxyhypusine synthase 0.008669
19 ENOG4108JIP Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) 0.008666
20 ENOG4108JIQ Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity) 0.008666
21 ENOG41060GV RNA binding s1 domain protein 0.008580
22 ENOG4105EHU Circadian clock protein KaiC 0.008565
23 ENOG41065MM DNA topoisomerase VI subunit A 0.004277
23 ENOG4105EIV DNA topoisomerase VI subunit B 0.004277
24 ENOG4105EBX v-type atpase 0.008540
25 ENOG4106J27 Removes the N-terminal methionine from nascent proteins (By similarity) 0.008479
26 ENOG4108X76 ATP binding protein 0.008465
27 ENOG4105D7D AAA ATPase 0.008463
28 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) 0.008444
29 ENOG41068N3 Peptidyl-tRNA hydrolase PTH2 0.008415
30 ENOG4108NGU Transcriptional regulator 0.008392
31 ENOG4105DK7 lysyl-tRNA synthetase 0.008371
32 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) -0.008347
33 ENOG4108ZT0 50S ribosomal protein l17 -0.008277
34 ENOG4105XPM ribosomal protein 0.008209
35 ENOG4107R56 PP-loop domain protein 0.008012
36 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) -0.007960
37 ENOG4105E9D metallophosphoesterase 0.007933
38 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) -0.007890
39 ENOG4105EM7 Selenocysteine-specific translation elongation factor 0.007727
40 ENOG4105D64 Mechanosensitive ion channel 0.007707
41 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) -0.007704
42 ENOG4105S77 Domain of unknown function DUF87 0.007565
43 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) -0.007565
44 ENOG4107WZZ SMC domain protein 0.007532
45 ENOG4105CY0 Metallo-Beta-Lactamase 0.007526
46 ENOG4105CYW agmatinase 0.007522
47 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) -0.007517
48 ENOG4105K5M 30s ribosomal protein S16 -0.007510
49 ENOG4105F23 Fibronectin-binding protein 0.007499
50 ENOG4107QNU type ii secretion system protein e 0.007475
51 ENOG4108ZDY Methyltransferase 0.007475
52 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) -0.007466
53 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) 0.007456
54 ENOG4107QR0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) 0.007356
55 ENOG4106Z6D Molecular chaperone capable of stabilizing a range of proteins (By similarity) 0.007338
56 ENOG4107TPF metallophosphoesterase 0.007293
57 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) -0.007287
58 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) -0.007227
59 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) -0.007195
60 ENOG41062C5 adenylate kinase 0.007132
61 ENOG4105CDU Replicative dna helicase -0.007106
62 ENOG4108FK2 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) 0.007043
63 ENOG4107RNT radical SAM domain protein 0.007026
64 ENOG4105NBF ammecr1 domain protein 0.007012
65 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) -0.007010
66 ENOG4105CX6 glutaminyL-tRNA synthetase 0.006933
67 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) -0.006915
68 ENOG4105C6E dna polymerase iii 0.006893
69 ENOG4105DCI Phosphohydrolase 0.006886
70 ENOG4105ZJM Archease protein family (MTH1598/TM1083) 0.006852
71 ENOG4105DHP deoxycytidine triphosphate deaminase 0.006797
72 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) 0.006741
73 ENOG4107TRG DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) 0.006707
74 ENOG4108RG4 adenine phosphoribosyltransferase 0.006694
75 ENOG4105E9C Xylose isomerase domain-containing protein 0.006599
76 ENOG4105PRY AsnC family transcriptional regulator 0.006563
77 ENOG4106WV3 Family transcriptional regulator 0.006559
78 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) -0.006528
79 ENOG41074MP UPF0103 Mediator of ErbB2-driven cell motility-containing protein 0.006517
80 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) 0.006421
81 ENOG4105CSM endonuclease III 0.006387
82 ENOG4108VT5 Ser Thr protein phosphatase family protein 0.006377
83 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) 0.006372
84 ENOG4105WHP Transcriptional regulator 0.006323
85 ENOG4105E0Y RtcB Protein 0.006323
86 ENOG4108ZRZ Transcriptional regulator (AsnC family) 0.006257
87 ENOG4108HXN Pfam:GSPII_E 0.006241
88 ENOG410692R Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) 0.006224
89 ENOG4108V9B metallophosphoesterase 0.006224
90 ENOG4105WR5 sporulation protein, YlmC YmxH family 0.006201
91 ENOG4105TUP type ii secretion system 0.006160
92 ENOG4105M7V 2'-5' rna ligase 0.006157
93 ENOG4105E8R UPF0173 metal-dependent hydrolase 0.006148
94 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) 0.006111
95 ENOG4105C5S asparaginyl-tRNA synthetase 0.006098
96 ENOG4105DQX Zinc finger domain 0.006062
97 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) -0.005990
98 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) -0.005975
99 ENOG41084J1 Integral membrane protein DUF95 0.005957
100 ENOG4107TC5 (phospho)adenosine phosphosulfate reductase 0.005953
101 ENOG4107ZAZ Oligosaccharyl transferase, STT3 subunit 0.005899
102 ENOG4105S1F Transposase 0.005881
103 ENOG4108UYR glutaredoxin-like domain protein 0.005841
104 ENOG4105VG1 fes assembly suf system protein 0.005838
105 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) -0.005821
106 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase 0.005818
107 ENOG4108VWZ crispr-associated protein Cas4 0.005815
108 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) 0.005814
109 ENOG4108ZFU Translin 0.005813
110 ENOG4107VT3 K03386 peroxiredoxin (alkyl hydroperoxide reductase subunit C) EC 1.11.1.15 0.005806
111 ENOG4108SXM bacteriophage DNA transposition B protein 0.005776
112 ENOG4107RBB ABC transporter, permease 0.005754
113 ENOG4108JZI Triose-phosphate isomerase 0.005736
114 ENOG4106TX1 NA 0.005733
115 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) 0.005730
116 ENOG4107V05 Dead deah box helicase domain protein 0.005728
117 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) 0.005717
118 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) 0.005712
119 ENOG4107R69 radical SAM domain protein 0.005675
120 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) 0.005665
121 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) 0.005663
122 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E 0.005643
123 ENOG4108Z4J Cytidine monophosphate kinase 0.005629
124 ENOG41069HS aspartate glutamate uridylate kinase 0.005600
125 ENOG4107XCR Uridylate kinase 0.005589
126 ENOG4105FEU K -dependent Na -Ca exchanger 0.005560
127 ENOG410682R Inherit from COG: UPF0282 protein 0.005547
128 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) -0.005539
129 ENOG4105SYT Methylenetetrahydrofolate reductase -0.005531
130 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) -0.005530
131 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) -0.005497
132 ENOG4108R9N radical SAM domain protein 0.005487
133 ENOG4107K5X Membrane-bound metal-dependent hydrolase 0.005480
134 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) 0.005462
135 ENOG4107UMW polysaccharide biosynthesis protein 0.005450
136 ENOG4107QK2 May be the GTPase, regulating ATP sulfurylase activity (By similarity) 0.005448
137 ENOG4105C9M aspartyl-trna synthetase -0.005411
138 ENOG4105C7R Atpase associated with various cellular activities aaa_3 0.005405
139 ENOG4105MX0 acetyl-coa acetyltransferase 0.005402
140 ENOG4105PP5 Peptidase, zinc-dependent 0.005373
141 ENOG4106CEC YHS domain-containing protein 0.005368
142 ENOG41086IP 50S ribosomal protein L33 0.005361
143 ENOG4108C5M glyceraldehyde-3-phosphate dehydrogenase 0.005346
144 ENOG4107S69 repeat protein 0.005325
145 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) -0.005313
146 ENOG41080MC Phospholipid-binding protein, PBP family 0.005256
147 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) 0.005224
148 ENOG4105J3N deoxyuridine 5'-triphosphate nucleotidohydrolase 0.005223
149 ENOG4105CFG Acts as a chaperone (By similarity) -0.005221
150 ENOG4105EBP faD-dependent pyridine nucleotide-disulfide oxidoreductase 0.005118
151 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) 0.005111
152 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) 0.005103
153 ENOG41076BV Domain of unknown function DUF120 0.005080
154 ENOG41082XB radical SAM domain protein 0.005058
155 ENOG4108IMY Transcriptional regulator 0.005057
156 ENOG4108T9W RNA methylase 0.005051
157 ENOG4105C0P Mg chelatase subunit ChlI 0.005035
158 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B 0.005032
159 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) -0.005032
160 ENOG4108FF3 Domain of unknown function (DUF1886) 0.005031
161 ENOG4105ECD TIGR00266 family 0.005008
162 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) -0.004992
163 ENOG41086FF competence protein ComEA helix-hairpin-helix repeat protein 0.004966
164 ENOG4108ZJT translation initiation factor, Sui1 0.004960
165 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) 0.004956
166 ENOG4105DAN ATP-dependent protease 0.004955
167 ENOG4105K9Q Binds to the 23S rRNA (By similarity) -0.004954
168 ENOG41087E9 Type 11 methyltransferase 0.004942
169 ENOG4107XB7 anaerobic ribonucleoside-triphosphate reductase activating protein 0.004938
170 ENOG4107ZG5 Binds to the 23S rRNA (By similarity) 0.004913
171 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) -0.004893
172 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving -0.004863
173 ENOG41084VF (ribosomal) protein 0.004856
174 ENOG4105C22 threonyL-tRNA synthetase 0.004855
175 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) 0.004842
176 ENOG4108RCS geranylgeranylglyceryl phosphate synthase 0.004798
177 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) -0.004787
178 ENOG4107FF9 50s ribosomal protein l29 0.004765
179 ENOG41068XN NA 0.004763
180 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) -0.004749
181 ENOG4106K5Q Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity) 0.004747
182 ENOG4106U9Y GHMP kinases N terminal domain 0.004742
183 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) -0.004697
184 ENOG410688J Ferredoxin 0.004689
185 ENOG4107I49 PRC-barrel domain protein 0.004685
186 ENOG4108PDR lipopolysaccharide core biosynthesis protein 0.004682
187 ENOG4108MDK Dehydrogenase 0.004682
188 ENOG4105EAC phosphoserine phosphatase 0.004682
189 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) -0.004680
190 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) -0.004675
191 ENOG4105H83 NA 0.004666
192 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) 0.004660
193 ENOG4107V84 geranylgeranyl reductase 0.004645
194 ENOG4108YZY peptidylprolyl cis-trans isomerase 0.004629
195 ENOG4108IYH Dna topoisomerase 0.004629
196 ENOG4106C6A Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) 0.004627
197 ENOG4108UJR mevalonate kinase 0.004613
198 ENOG4107R58 glycosyl transferase group 1 0.004609
199 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) -0.004598
200 ENOG4105E66 phosphoriboisomerase A 0.004596
201 ENOG4108FG8 Inherit from COG: tRNA -(guanine-N1)-methyltransferase 0.004586
202 ENOG4108TN5 Domain of unknown function DUF128 0.004573
203 ENOG4108V5K nudix hydrolase 0.004561
204 ENOG4105W0E 50S ribosomal protein L33 -0.004554
205 ENOG4105CUT histidyl-tRNA synthetase 0.004536
206 ENOG41081XM Histidine triad (HIT) protein 0.004533
207 ENOG4106PFM Protein of unknown function DUF137 0.004532
208 ENOG4108HP6 NA 0.004528
209 ENOG4105XDF Protein of unknown function (DUF1272) 0.004524
210 ENOG4105CRK lysyL-tRNA synthetase -0.004524
211 ENOG4106CD4 NA 0.004518
212 ENOG4107RZZ dna polymerase iii epsilon subunit -0.004512
213 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) 0.004495
214 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) -0.004476
215 ENOG4106CHK Nucleic-acid-binding protein containing a Zn-ribbon 0.004474
216 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) -0.004462
217 ENOG4107SS4 tRNA pseudouridine synthase d 0.004461
218 ENOG4108UEH D-aminoacyl-tRNA deacylase 0.004453
219 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) -0.004451
220 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) -0.004450
221 ENOG410908M cytochrome C biogenesis 0.004447
222 ENOG4105KK6 nuclease 0.004446
223 ENOG4106867 Phosphate-starvation-inducible E 0.004442
224 ENOG4105HH0 DNA-binding protein hu 0.004435
225 ENOG4105M23 ATP synthase subunit C 0.004434
226 ENOG4105VJV 50s ribosomal protein L35 -0.004434
227 ENOG410625Q Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) 0.004423
228 ENOG4105JV6 serine threonine protein kinase 0.004422
229 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) -0.004413
230 ENOG4108YZ8 Superoxide reductase 0.004401
231 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) 0.004393
232 ENOG4105C3G gtp-binding protein 0.004392
233 ENOG4105CTD carboxy-peptidase 0.004385
234 ENOG4105F4G Membrane 0.004380
235 ENOG4106KZE Peptidase M50 0.004378
236 ENOG4105CP7 Triose-phosphate isomerase -0.004375
237 ENOG4105F0N pyrophosphate phospho-hydrolase 0.004356
238 ENOG4105N8K Putative integral membrane protein DUF46 0.004354
239 ENOG4105E25 NA 0.004343
240 ENOG410631U NA 0.004342
241 ENOG4105K59 histidine triad (HIT) protein 0.004339
242 ENOG4107VR3 Phosphoesterase, PA-phosphatase related 0.004320
243 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) 0.004314
244 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) 0.004314
245 ENOG4105D82 Glutamate dehydrogenase 0.004310
246 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) 0.004300
247 ENOG4108RKK Nucleotidyl transferase 0.004299
248 ENOG4107S3E Type III restriction enzyme, res subunit 0.004281
249 ENOG4107DHM Serine hydroxymethyltransferase 0.004263